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Some studies have revealed the intense expression of SOD1 in astrocytes (Lindenau et al., 2000, Noack et al., 1998), while others have failed to identify their expression (Moreno et al., 1997, Thaete et al., 1986) and few studies have partially identified it in the form of scattering in some astrocytes (Furuta et al., 1995, Pardo et al., 1995)

Exp Mol Med (2022) 54(4):50317

Russell et al., 2023), which leads to the release of ligands for EGFR, stimulates the innate immune response of epithelial cells by activating EGFR (Ho et al., 2019)

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However, without metal nanoparticles of high atomic number, the effect of radiotherapy sensitization is not satisfactory