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Proinflammatory cytokines also induce O&NS pathways and by generating an increase in ROS in the electron transport chain deplete glutathione [109]

In this cycle, GSH is released from the cell by carrier mediated transporter(s) and the ecto-enzyme GGT then transfers the -glutamyl moiety of GSH to an amino acid (the best acceptor being cystine), forming -glutamyl amino acid and cysteinylglycine

in which it is located, is known as the City of the Sacred Lake, since Lake Titicaca is located on its lands, famous for having been the Pacarina, from which, according to the myth, Manco Cpac and Mama Oclo