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Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2

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By establishing UBE3C as a regulator of m6A RNA methylation through targeted degradation of Cbll1, we extend the ubiquitin code into the realm of epitranscriptomic control

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Individuals with preexisting hyperprolactinemia or adrenal-axis concerns should not use MK-677 without specialist oversight