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Nevertheless, -syn levels were significantly decreased (Fig

Tamoxifen induces apoptosis in P-gp expressing cells To determine if tamoxifen-induced collateral sensitivity of drug resistant cells is due to enhanced apoptosis, AuxB1 and CHO R C5 cells were treated with tamoxifen for 24 h and then examined for the presence of apoptotic cells using FITC-conjugated annexin-V and cell staining with Hoechst Dye