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Description

Chem Res Toxicol 2009

-Butyrobetaine is a proatherogenic intermediate in gut microbial metabolism of L-carnitine to TMAO

PubMed: 17921186

Mechanistically, BL-mediated protection involves downregulation of IFN- production, attenuation of cytotoxic microglial activation and CD4 + T cell responses, expansion of Treg populations, and suppression of Th17 cell differentiation