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[6] In all cases, a healthcare provider should evaluate patient history for any contraindication before initiating therapy

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For example, several studies support a causal relationship between augmented NNMT activity in cancer cells and tumor proliferation/progression in a variety of cancerous states with potential implications for NNMT as a biomarker for cancer prognosis and a relevant target for anti-cancer therapeutic development

We replace any folic acidcontaining supplements with L-methylfolate (or sometimes folinic acid) and a high-quality B-complex that uses active forms

This is then stored in the liver for future use