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Methods: We developed a biomimetic autophagy degradation peptide (MNP-PDL1) using the lysosomal autophagy system in conjunction with biomimetic membrane technology, which consists of a PD-L1-binding sequence, a PEG3 linker, and a target lysosomal chaperone protein recognition sequence (CIP), which can localize the target protein, PD-L1, to the lysosome for degradation

PMID: 40494050 Brain Behav A Preliminary Study of Effect of Melatonin on Inflammation and Hypoxia-Related Factors in a Mouse Model of Elastase-Induced Intracranial Aneurysm

To this purpose, tumour BT474 and BT474-R cells, BJ fibroblasts and HuVEC endothelial cells were bio-printed in Cellink GelXA LAMININK 411 bioink and their growth followed for up to a month with regular assessment of their viability by Live/Dead staining

A cross-sectional study based on NHANES 2003-2004 data from 2,638 participants ages 40 years and over found that the risk of high blood pressure (hypertension), a major contributing factor for CVD, was 73% higher in individuals in the upper versus lowest quintile of serum selenium concentrations (150 g/L vs

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