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ElnabawiYAGarshickMSTawilMBarrettTJFisherEALo SiccoKet alCCL20 in psoriasis: a potential biomarker of disease severity, inflammation, and impaired vascular health

A study involving Ang II-induced aortic aneurysms in mice suggested that ALDH2 deficiency may enhance susceptibility to abdominal aortic aneurysm formation by diminishing anti-ROS effects and increasing VSMC apoptosis and vascular inflammation (100)

Extracellular mutant SOD1 induces microglial-mediated motoneuron injury

In conclusion, oxidative stress is involved in several aspects of CAP, including immunity and inflammation

Together, these examples underscore the importance of studying metabolic remodeling during human neurodevelopment and emphasize the need for reliable, neuron-specific model systems that can recapitulate early stages of differentiation and bioenergetic specialization