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JAMA 327 , 138150 (2022)

Research Verdict: When to Use Each or Both Choose BPC-157 When Research Focuses On: Gastrointestinal healing and protection Tendon and ligament injuries Nerve regeneration and neuroprotection Situations requiring oral administration Protection from NSAID or other toxic damage Choose TB-500 When Research Focuses On: Cardiac tissue repair and cardioprotection Wound healing and scar reduction Systemic anti-inflammatory effects Muscle regeneration Hair follicle research Consider Combination When: Comprehensive tissue repair is the goal (e.g., complex injury involving multiple tissue types) Maximizing angiogenesis AND cell migration is desired Research hypothesis involves sequential healing phases Mechanistic Rationale for Stacking: The combination addresses different phases of healingBPC-157 promotes blood vessel ingrowth and initial cytoprotection, while TB-500 facilitates the cellular repair and remodeling that follows vascularization

doi:10.4161/jkst.25763 234

3.2.2 Safety A total of 16 TEAEs were reported in nine participants

PMCID: PMC3296184