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Metformin may adversely affect orthostatic blood pressure recovery in patients with type 2 diabetes: Substudy from the placebo-controlled Copenhagen Insulin and Metformin Therapy (CIMT) trial

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[3] The doses used in these tendon studies typically ranged from 10 to 200 micrograms per kilogram of body weight, administered once daily, which when extrapolated to a 75-kilogram human would suggest a working range of approximately 200 to 500 micrograms per day