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There is no known cause of IC/PBS but it does tend to occur more often in women with auto-immune disorders such as fibromyalgia and rheumatoid arthritis, and this condition affects women significantly more often than men

Therefore, it is understandable that most drugs had moderate effects at best

The American journal of clinical nutrition , 50 (4), 818824

The brand matters less than the specification

After infusion, they circulate quickly, support metabolism, nerve function, and energy production, and then excess amounts are flushed out through urine, often within several hours to about a day