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GLP-1R is expressed in the brainstem nucleus tractus solitarius, in the hypothalamic arcuate nucleus, in the vagus nerve, in the stomach, and in the heart

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29 A short half-life is often problematic with neuropsychiatric medications because rapid washout can be associated with drug withdrawal symptoms as with benzodiazepines or with drug discontinuation syndromes as with antidepressants

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This type of immune reaction may be triggered by an infection or, in rare cases, certain vaccines