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Secondary injury involves a series of pathological events, such as ischemia, oxidative stress, inflammatory events, apoptotic pathways, and motor dysfunction

developed biodegradable nanocomposite microspheres encapsulating DFP to enhance mucoadhesion and sustain drug release for nasal administration ( in vitro and in vivo efficacy data are still lacking

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It does not evaluate actual airway responses, but is based on the notion of the nature of immune responses elicited in mice by chemical allergens and of the qualitative differences in immune responses provoked by contact and respiratory sensitizers as they are generally found