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Papke RL, Horenstein NA (2021) Therapeutic targeting of 7 nicotinic acetylcholine receptors

Orthogonal cyclization strategies, including head-to-tail, side-chain to side-chain (e.g., disulfide bridges, lactam bonds, hydrocarbon staples), and backbone cyclization, enhance conformational rigidity and proteolytic resistance

Es wurde in prklinischen Modellen fr die gewebebezogene Forschung untersucht

doi: 10.1210/jcem.85.8.6720 74 BastardJPJardelCBruckertEBlondyPCapeauJLavilleMet al

These mitochondrial alterations result in reduced inter-organelle communication, impaired organelle turnover, and a loss of metabolic plasticity and mitochondrial dynamics