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This depletion causes NAPQI to covalently bind to macromolecules, particularly proteins, which subsequently leads to malfunction of the mitochondria

Inhibition of mTORC1 reduces translation-related stress, limits the production of misfolded proteins, and alleviates oxidative damage

*Helps in arthritis, high cholesterol levels, diabetes, cancer and other chronic diseases

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Indications for amlodipine include left ventricular hypertrophy, asymptomatic atherosclerosis, angina pectoris, vasospastic angina, peripheral artery disease, metabolic syndrome, and, in the elderly, isolated systolic hypertension 18,19,20