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Unrestrained replication fork progression in HRASV12- or cyclin E1-overexpressing cells depends on proteins involved in restarting R-loop-stalled forks The unrestrained replication fork progression induced by PARP inhibition in cells treated with R-loop-inducing drugs is dependent on the MUS81-EME1 endonuclease, the DNA helicase RECQ1, the DNA ligase IV (LIG4), and the transcription elongation factor ELL, among others 14,27

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