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If you don't already know about what's been learned about the impact of ACEs, I found a good writeup at mft.nhs.uk/rmch/services/ca

162 RenX.ChenZ.LiuY.ZhangH.ZhangM.LiuQ.et al

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The accumulation of intermediate metabolite N-acetyl-GABA in primary cultured astrocytes on genetic ablation of the enzyme as well as the uninterrupted H 2 O 2 production on SIRT2 inhibition (Fig