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GIP has been shown to decrease food intake & increase energy expenditure therefore resulting in weight reductions & when combined with GLP-1 receptor agonism, may result in greater effects on markers of metabolic dysregulation such as body weight, glucose, & lipides

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In contrast, smaller molecules can enter the pores of the beads, causing them to elute more slowly as they need to navigate through the pore network

GPCRs that are agonist-activated promote the synthesis of guanine triphosphate (GTP), which when bound to the G-protein causes the Ga and Gbc subunits to separate, which in turn can activate signaling proteins downstream [52]

Changing in pH and salt concentration will alter electrostatic interactions between charged amino acids