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Conclusion: This study conclusively demonstrates that Pg , compared to Fn and Sm , plays a critical role in elevating plasma TMAO levels and significantly influences the TMA-TMAO pathway, primarily by modulating the expression of hepatic FMO3 and directly impacting hepatic lipid metabolism

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Mice in the NC and NA cohorts were exposed to normoxic conditions (21% O 2 ) from birth, while those in the HO and HA cohorts were subjected to hyperoxic conditions (95% O 2 ) for 7 days