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Research theme: Biochemistry Biochemical properties of TRP14 (TXNDC17) The thioredoxin-fold protein named TRP14 (thioredoxin Related Protein of 14 kDa), which is encoded by TXNDC17 in human (for thioredoxin domain-containing 17), is an interesting and little-studied protein that is ubiquitously expressed in cells in parallel with thioredoxin, a good substrate for thioredoxin reductase, but is not capable of reducing typical thioredoxin substrates such as ribonucleotide reductase, peroxiredoxins or methionine sulfoxide reductases

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191,192,193 In the small intestine, ZnT2 assumes a vital function in cytoplasmic zinc buffering, which is essential to Toll-like receptor 4 (TLR4) expression, initiation of pathogen-activated NF- translocation, in addition to the release of cytokine in response to infectious challenges

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