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Some PA patients appear to be able to respond to 'mega-doses' of oral B12 however, but this situation needs very careful management because it's not yet possible to work out who will benefit without a clinical trial

The clinical trials that showed disappointing results used oral administration

In some rare cases, false-positive or false-negative results may occur

GHK-Cu may prevent oxidative stress in skin by regulating copper and antioxidant gene expression. Oxidative Medicine and Cellular Longevity , 2018, Article ID 3235918