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All experimental groups were fed a high-sugar, high-fat diet

Supplementation with serine and an NAD + precursor, like tryptophan, niacin, or nicotinamide riboside (NR), along with NAC are expected to increase NAD+, glutathione, and fat oxidation in the liver, leading to lower levels of oxidative stress, resulting in lower hepatic steatosis and its progression

Another remarkable feature of cells undergoing apoptosis is that they rapidly and selectively release a large fraction of their intracellular GSH into the extracellular space (van den Dobbelsteen et al., 1996

Indeed, pyridoxal phosphate, the active form of pyridoxine, has been found to have independent neuroprotective potential

Hypertension (Dallas, Tex: 1979) 73(2):449457