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Furthermore, although AD brain tissue frequently exhibits mitochondrial failure, new research has shown that peripheral mononuclear blood cells' mitochondrial activities have changed ( 3.2 Impaired electron transport chain function Alzheimer's disease is marked by decreased activity in several enzymatic complexes critical for ATP production, including the pyruvate dehydrogenase complex, -ketoglutarate dehydrogenase complex, complex I (NADH ubiquinone oxidoreductase), complex IV (cytochrome oxidase), and complex V (ATPase) (43, 44)

In some studies, the serum level of DAO was used as a selection criteria [37,87]

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