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Nilius, J.G

M.HalwesM.NisbetD.CollinsD

Ethanol may have the capacity to elevate the activity of nicotinamide adenine dinucleotide phosphate oxidase (NOX) or NADPH Oxidase enzymes, which, in turn, can lead to the formation of ROS [180]

In such situations, the light chain should be placed before the heavy chain to avoid an excess of toxic free heavy chain (Proudfoot, Nature 322:52 (1986)