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Thus, it needs to be cleared out quickly to prevent cell and DNA damage, which can lead to cancerous mutations.[ref] Two well-studied genetic variants have different ways of reaching the same endpoint: ~ an alcohol dehydrogenase (ADH1B) variant that speeds up the conversion to acetaldehyde, thus creating a buildup of acetaldehyde ~ an acetaldehyde dehydrogenase (ALDH2) variant that slows down the conversion from acetaldehyde to acetic acid, again creating a buildup of acetaldehyde

doi: 10.3109/10717544.2014.907372 231

[] These are ancient classic prescriptions of TCM for chest-bi/cardiac pain by modulating the liver

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These findings suggest that while high doses of rhamnetin may pose risks, its therapeutic potential can be safely harnessed when administered within an appropriate dosing regimen [113]