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In addition to off-target effects, other clinical limitations further constrain the translational potential of these mitochondrial DNA editing tools

Ania MJ, Louis JA, Nadia NA, Sean W, Lisa C, Breno A, et al

Although research on intranasal administration of BPC-157 is extremely limited, broad studies on the potential benefits of intranasally administered peptide therapeutics suggest that this may be a beneficial RoA [11, 12]

Consistent with the above findings, the down-regulation of CPT1A, CPT2, and LCAD gene and protein expression by VPA was found to be significantly greater than that of SCAD and MCAD in the present study

ROS promote epithelial-mesenchymal transition (EMT), migration, invasion (e.g., by regulating MMPs), and survival of circulating tumor cells from anoikis and oxidative stress within the blood circulation [32]