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10.1016/j.jbc.2024.107752 211

GPx2 is expressed predominantly in the gastrointestinal tract and is considered the first protective barrier against the absorption of hydroperoxides from processed food

however, some studies have demonstrated limited benefits of intensive glycemic control for T2D patients as only modestly prevents or delays the progression of DPN and CAN in patients with T2D, possibly because of undiagnosed hyperglycemia and multiple combined risk factors