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Organs such as brain and heart, with high rates of oxygen consumption and limited respiration levels, are particularly vulnerable to this phenomenon, hence partially explaining the high prevalence of cardiovascular diseases (CVD) and neurological disorders in elderly (Corbi et al., 2008)

While no significant adverse reactions have been reported in animal experiments and human clinical trials to date, Di Stefano et al

doi: 10.5713/ajas.2004.1741 105 PatrignaniF.LanciottiR.MatharaJ

6 Conclusion and outlook In conclusion, preclinical studies of PPS in cellular and animal models demonstrate promising antitumor efficacy

Such diseases include a variety of disorders like stroke, heart failure, myocardial infarction, and hypertension