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This bidirectional regulatory process involves multiple interrelated mechanisms, including dysregulation of local prolactin synthesis and secretion (e.g., originating from adipose tissue or other extrapituitary tissues), alterations in prolactin metabolism and clearance processes, and a persistent chronic low-grade inflammatory state ( Figure 2 )

The phytoestrogen coumestrol is a naturally occurring antagonist of the human pregnane X receptor

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Moreover, antiarrhythmic pharmacotherapies themselves increase the risk of life-threatening arrhythmias [11,12]

10.3390/ph18091360 12 BertonO.NestlerE