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In a rat model of intervertebral disc degeneration, MOTS-c injection preserved disc height (82.4% versus 58.7% in the untreated group), restored MRI signals indicating improved disc hydration, and reduced histological degeneration scores by 44% compared to untreated controls

Post-infection gut dysbiosis drives systemic inflammation, leaky gut, and immune dysregulation all of which amplify fatigue, cognitive impairment, and mood instability.3 BPC-157 has been shown in multiple animal studies to: Accelerate healing of the intestinal epithelium4 Reduce gut inflammation and restore tight junction integrity5 Modulate the vagus nerve, which connects gut function to brain and immune signaling6 For long COVID patients dealing with GI symptoms, food intolerances, or fatigue that tracks with gut dysfunction, this mechanism is directly relevant

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doi: 10.1021/cr050531b 42