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Visible wrinkle and firmness improvements typically show up between weeks 6 and 12, matching the timeline in published clinical studies

Since microtubules play an important role in maintaining cell morphology, establishing cell polarity, and intracellular information transmission, hyperphosphorylated Tau protein could result in the loss of affinity with microtubules and lead to microtubules unstable and disintegrated, which in turn affects the transport and morphological structure of nerve cells, leading to the death of nerve cells [38, 39]