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Clinical Trial Findings Oral Bioavailability Challenge: Randomized controlled trials (RCTs) on standard oral GSH supplementation show mixed and controversial results

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In cancer, the delicate balance of proteostasis is often disrupted, leading to the accumulation of misfolded or damaged proteins, aberrant signaling pathways, and genomic instability, all of which contribute to tumorigenesis and cancer progression

A pooled analysis of two randomized trials showed that SBRT and pembrolizumab combined with trametinib were a new potential treatment option for patients with locally recurrent pancreatic cancer following surgical resection (157)

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