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Furthermore, diminished METTL3 expression in MSCs reduces protein synthesis of parathyroid hormone receptor-1 (Pth1r), thus decreasing translation efficiency and suppressing the activation of protein kinase A (PKA) and extracellular signal-regulated kinase (ERK) pathways, leading to reduced osteogenic differentiation [92]

However, these findings require further validation through large-scale studies encompassing diverse diets and countries

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