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A prime example is interferon (IFN), which may upregulate HLA class I heavy chains (2m, TAP1, TAP2, or Tapasin) and cause HLA-I to be downregulated when it is impaired (83)

Differentiating between tight junction-dependent and tight junction-independent intestinal barrier loss in vivo

It could not, however, reduce dehydroascorbic acid or ubiquinone

This can occur, for instance, through partial inhibition of replicative DNA polymerases with aphidicolin or under conditions of excessive generation of ROS 14 , which promote dissociation of the fork acceleration factor TIMELESS-TIPIN from the replisome in a manner dependent on the replisome-associated ROS-sensor PRDX2 51

However, if that process is somehow interrupted you can end up with free radicals