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In vivo pharmacodynamic and pharmacokinetic effects of metformin mediated by the gut microbiota in rats

binds GLP-1 receptors on pancreatic -cells (stimulating glucose-dependent insulin secretion), -cells (suppressing glucagon), gastrointestinal tract (slowing gastric emptying), and hypothalamic neurons (suppressing appetite and food intake via arcuate nucleus signaling)

Material and methods Study strategy and experimental design Aiming to investigate whether CBD- and THC-based oils protect the brain from the toxic effects of Al, we used adult zebrafish as an animal model organism

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