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Metabolic dead-ends were then identified using the GapFind algorithm 36 and were subsequently filled in by the addition of new reactions from other organisms based on literature evidences

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Prognosis A long-term follow up study of 28 patients with glutathione synthetase deficiency has showed that the factors most predictive of survival and long-term outcome are early diagnosis, correction of acidosis and early supplementation with vitamin C and vitamin E [19]

Artemisinin has poor water and fat solubility, poor stability, and low oral bioavailability, limiting its clinical applications (Yu et al., 2012)