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These typically include medications for certain infections, cancer treatments, medications derived from human sources that carry disease transmission risks, and specific teratogenic drugs

So, it is believed that they cannot convert prednisone to prednisolone through metabolism efficiently

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The enhanced T4 to T3 conversion with adequate growth hormone theoretically improves thyroid hormone activity, potentially explaining some metabolic benefits of growth hormone therapy

doi: 10.1038/nri.2017.52 197 SundiD.CollierK