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Annu Rev Pharmacol Toxicol 64:405425

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Lack of critical involvement of caspase-3 in eryptosis has been emphasized in an extensive analysis of the caspase-3 contribution to eryptosis, which has revealed that eryptosis triggered in vitro by diverse compounds is not associated with caspase-3 recruitment in the majority of cases [84]

Ultrastructural analysis by transmission electron microscopy further suggested that in the TB-500 group, the newly formed collagen fibrils tended to be thicker, with diameters extending up to around 87 nm, compared to a maximum of 62 nm in control tissue