he effects of stress and aging on glutathione metabolism Frontiers Functional Consequences of Age-Dependent Changes

Epigenetic and DNA binding effects Beyond telomerase activation, epitalon has been shown to bind preferentially to methylated cytosine in DNA and to interact with linker histone proteins H1.3 and H1.6

[DOI] [PubMed] [Google Scholar] 50.Savilov P.N., Yakovlev V.N

Ridder et al

Clin Cancer Res 19: 560570 Horiguchi M, Koyanagi S, Okamoto A, Suzuki SO, Matsunaga N, Ohdo S (2012) Stressregulated transcription factor ATF4 promotes neoplastic transformation by suppressing expression of the INK4a/ARF cell senescence factors

Iron deficiency and iron overload are considered important causes of chronic metabolic diseases (such as T2DM or obesity) [108] Studies have shown that mice fed with rich iron diets showed upregulation of IR-related adipokines because an iron-enriched diet induces insulin resistance and hypertriglyceridemia and affects visceral adipose tissue metabolism by a mechanism involving hepcidin up-regulation [109]