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This is attributed to the heightened levels of NNMT potentially rendering NAM irretrievable, thereby constraining NAD + -dependent processes (Trammell and Brenner, 2015)

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5-oxoproline is an amino acid derivative within the -glutamyl cycle within the liver, When gluathione stores are depleted -glutamycycteine synthase activity increases in an attempt to replenish the glutathione stores

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