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Imaging techniques (i.e., ERCP) have also shown biliary tract calculi in many patients with established PSC, suggesting the removal of calculi as an exclusionary criterion (Kaw et al, 1995)

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10.1073/pnas.1512131112 Proc

Cancer cells also need to keep ROS production under control, and glutamine converted in glutamate serves the synthesis of glutathione peroxidase as a major anti-oxidative enzyme from glutamine

However, the dosing regimen has to be adjusted to maximize concentration of glutathione in the blood and bioavailability studies are warranted prior to designing the treatment protocol