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Throughout the experiment, animals were maintained under anaesthesia, and artificial cerebrospinal fluid (NaH 2 PO 4 2.0 mM, MgCl 2 1.0 mM, CaCl 2 1.2 mM, KCl 2.7 mM and NaCl 145 mM) was constantly pumped through the microdialysis probe at a rate of 0.5 L/min