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A study also found that aging cells gradually accumulated in the visceral white adipose tissue and liver during aging, and the inflammatory cytokines secreted by aging cells (representing the senescence-associated secretory phenotype, SASP) induced macrophage proliferation and the expression of CD38 ( In vitro , it was found that lipopolysaccharide (LPS) in macrophages could upregulate the expression of CD38 in a time-and-dose-dependent manner

Clinical studies have shown that early postpartum women with peripartum cardiomyopathy exhibit significantly higher CD38+ cells compared to postpartum women without cardiomyopathy [36]

However, only 22% of the variation in MMA levels was explained by vitamin B12, estimated glomerular filtration rate, age, sex, and socioeconomic status, suggesting that other underlying disease was likely the reason for elevated MMA levels

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(2022, March 24)