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If CBF is not restored in time, microcirculation abnormalities in the ischemic core and penumbra will be closely associated with inflammatory cell infiltration, microthrombosis, vascular endothelial cell damage, and other variables

A specific oxidoreductase, previously known as apoptosis-inducing-factor mitochondrial-2 (AIFM2), capable of recycling reduced ubiquinol (Co-enzymeQ 10 H 2 ) from ubiquinone at the expense of NAD(P)H, has been presented as a potential ferroptosis inhibitor due to the fact that its overexpression complements the loss of GPx4 in PFA1 and human fibrosarcoma (66, 67)

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Other Regenerative Peptides BPC-157 and TB-500 offer regenerative benefits without copper involvement

The review also discusses emerging therapeutic strategies aimed at targeting the hypoxic pathways, including the application of HIF-1 inhibitors, mTOR inhibitors, and other modulators of the hypoxic response