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In clinical trials, capsaicin also shows to alleviate uremic conditions in patients with CKD (Makhlough et al., 2010

& Miyazawa, T

Casillo A, Papa R, Ricciardelli A, Sannino F, Ziaco M, Tilotta M, Selan L, Marino G, Corsaro MM, Tutino ML, Artini M, Parrilli E (2017) Anti-biofilm activity of a long-chain fatty aldehyde from antarctic Pseudoalteromonas haloplanktis TAC125 against Staphylococcus epidermidis biofilm

LTA4 is ultimately converted, under the action of LTA4 hydrolase (LTA4H), into LTB4, which is encapsulated within exosomes for release (82)

Then, they conducted an untargeted metabolite profiling using serum and retinal from newborn mouse pups exposed to phosphate-buffered saline or roxadustat, and pointed out that HIF stabilization by roxadustat acivates serine and 1-carbon metabolism (1CM)