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The research rationale established by NNMT-knockdown studies in diet-induced-obese mice is that inhibiting NNMT preserves intracellular NAD+ and SAM levels, which in adipocyte (fat-cell) models has been shown to suppress de novo lipogenesis

doi:10.1038/s41598-024-65310-y Neelakantan H, Hommel JD, Watowich SJ, et al

Metabolic studies of a synthetic lipolytic domain (AOD9604) of human growth hormone in vitro and in vivo

The clinical range is 0-40 mm/hr, so it is rare to see this flagged but common to see a functional high level