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19 We speculate that patients with clEDS may be more prone to have structural defects along the walls of the gastrointestinal tract, which can predispose to diffuse diverticulosis, diverticulitis, and resulting bowel perforation as well as to perforation during invasive procedures and spontaneous perforation

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Most research protocols require 1216 weeks of consistent daily dosing before measurable changes in hair density or shaft diameter become observable

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