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Considering that nerve cells are continuously submitted to low-grade toxic insults, including oxidative and proteotoxic stress, a reinforcement of proteostasis induced by transcriptional modulation might help preventing brain degeneration

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Differences in the response of drugs in animals and in man, and, in particular, differences in drug metabolism, bioactivation and disposition, stimulated the search for human relevant experimental models that could replace the use of animals for human safety assessment and prediction

Bioinformatic analysis Bioinformatics analyses were performed using Bioconductor packages in the R language [59] as well as the Jamovi (The jamovi project (2024)

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