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Chronic pharmacological potentiation of this pathway could theoretically promote tumor development or progression in individuals with pre-existing pre-malignant cells

I have been being treated with B12

doi:10.1291/hypres.30.775 Tomou EM, Papakyriakopoulou P, Skaltsa H, Valsami G, Kadoglou NPE

This mechanistic insight is strongly supported by in vivo evidence showing that anti-OPN antibodies, which mimic the effect of blocking thrombin-cleaved OPN, replicate a tumor suppression phenotype in knock-in mice engineered with a thrombin cleavage-resistant form of the protein [271]