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Furthermore, CD4+ and CD8+ T cells in the TME often exhibit functional impairment, inactivation, or exhaustion, and frequently co-express multiple immune checkpoint molecules, such as PD-1, lymphocyte activation gene 3, and T cell immunoglobulin and mucin domain-containing protein 3 (TIM-3)

2023 [PubMed] [Google Scholar] 38.OMalley R, Rao G, Stein P et al

doi: 10.1038/ijo.2012.208 236 LockieSHHeppnerKMChaudharyNChabenneJRMorganDAVeyrat-DurebexCet al